Calcineurin Promotes Infection of the Cornea by Candida albicans and can be Targeted to Enhance Fluconazole Therapy 2 Running Title: Calcineurin Targeted Treatment of C. albicans Keratomycosis 4
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چکیده
6 Departments of Molecular Genetics and Microbiology, 1 Medicine, 2 and Pharmacology and Cancer Biology, 3 and Duke University Eye Center, 4 8 Duke University Medical Center, Durham, North Carolina 27710 Abstract: 50 words 10 Text: 996 words *Correspondence to either: 12 Dr. Afshari at Department of Ophthalmology Wadsworth Bldg, Box 3802, Erwin Road 14 Duke University Eye Center, Durham, NC 27710 Telephone: (919) 684-3799 Fax: (919) 681-7661 16 Email: [email protected] OR 18 Dr. Heitman at Department of Molecular Genetic and Microbiology 322 Carl Building, Box 3546, Research Drive 20 Duke University Medical Center, Durham, NC 27710 Telephone: (919) 684-2824 Fax: (919) 684-5458 22 Email: [email protected] A CE PT ED Copyright © 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00393-06 AAC Accepts, published online ahead of print on 21 August 2006
منابع مشابه
Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.
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